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Substance abuse is a pattern of continued harmful use of a mood altering substance, that results in adverse social consequences, such as failure to meet work, family, or school obligations, interpersonal conflicts, or legal problems. Substance abuse may lead to addiction or substance dependence. Medicaly, dependence requires the development of tolerance leading to withdrawal symptoms. Both abuse and dependence are distinct from addiction which involves a compulsion to continue using the substance despite the negative consequences, and may or may not involve chemical dependency. Dependence almost always implies abuse, but abuse frequently occurs without dependence, particularly when an individual first begins to abuse a substance. Dependence involves physiological proceses while substance abuse reflects a complex interaction between the individual, the abused substance and society.

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Structural Brain Correlates of MDMA Use

PI: Nancy Honeycutt, PhD
IRB # 04-06-28-03

The aim of this study is to examine the effects MDMA has on the hippocampal, amygdaloid and striatal structures and the relationship between drug-induced damage and neuropsychological function. In addition, this study will help elucidate the impact of MDMA on temporal lobe physiology and subsequent learning/memory, emotional recognition and impulsivity between MDMA users, polydrug users, and normals. Further, gender differences in response to MDMA use will be investigated. For questions about this study or if you would like to participate, please contact Vanessa Johnson at 410-502-0487.