__SEARCH
_
_ PNI Web Johns Hopkins

 

 

Bipolar Affective Disorder, Bipolar Disorder, "BPAD", or "BP" is a mood disorder typically characterized by fluctuations between manic and depressive states; and, more generally, atypical mood regulation and mood instability. Bipolar disorder, as with all mental disorders, is now generally considered to be a biochemical disorder of the brain and its associated hormonal systems. There is no definitive biochemical test for the disorder, nor is there any test for its absence, although there has been some success in identifying blood flow patterns in the brain using brain imaging. Bipolar disorder is found in disproportionate numbers in people with creative talent such as artists, musicians, authors, poets, and scientists, and it has been speculated that the mechanisms which cause the disorder may be related to those responsible for creativity in these persons. Many of these creative talents were "diagnosed" with bipolar disorder after their deaths and thus the diagnoses are unverifiable.

(Source: Wikipedia. For more info click here...)

Virology and Bipolar Disorder

PIs: Susan Bassett, PhD
in collaboration with Dr. Jennifer Payne (Johns Hopkins mood Disorder Center)
IRB # 05-03-28-02

The aim of this study is to examine hemodynamic activation (using fMRI) in a group of individuals with bipolar disorder and HSV-1 infection. The purpose of this study is to gain a better understanding of the pathologic mechanism involved in cognition in bipolar disorder and, perhaps more importantly, identify a population of individuals with the disease for whom anti-viral intervention may ameliorate a substantial burden of disease and disability. For questions about this study, please contact Catherine Cristinzio at 410-955-2754.


Neuroimaging in Bipolar Disorder

PIs: Susan Bassett, PhD and John Little, MD
IRB # 02-10-11-01

This study is funded by the Stanley Medical Research Institute. The aim of this study is to use neuro-imaging to help refine bipolar phenotypes, which may further the identification of genes related to bipolar disorder, assist with understanding treatment response, and provide clues about disease etiology.

-- This project is now completed --