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Bipolar Affective Disorder, Bipolar Disorder, "BPAD", or "BP" is a mood disorder typically characterized by fluctuations between manic and depressive states; and, more generally, atypical mood regulation and mood instability. Bipolar disorder, as with all mental disorders, is now generally considered to be a biochemical disorder of the brain and its associated hormonal systems. There is no definitive biochemical test for the disorder, nor is there any test for its absence, although there has been some success in identifying blood flow patterns in the brain using brain imaging. Bipolar disorder is found in disproportionate numbers in people with creative talent such as artists, musicians, authors, poets, and scientists, and it has been speculated that the mechanisms which cause the disorder may be related to those responsible for creativity in these persons. Many of these creative talents were "diagnosed" with bipolar disorder after their deaths and thus the diagnoses are unverifiable.

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Neuroimaging in Bipolar Disorder

PIs: Susan Bassett, PhD and John Little, MD
IRB # 02-10-11-01

This study is funded by the Stanley Medical Research Institute. The aim of this study is to use neuro-imaging to help refine bipolar phenotypes, which may further the identification of genes related to bipolar disorder, assist with understanding treatment response, and provide clues about disease etiology.

-- This project is now completed --


Virology, Genes and Bipolar Disorder

PIs: Susan Bassett, PhD and Sarah Reading, MD
in collaboration with Drs. Robert Yolken and Faith Dickerson (Sheppard Pratt Health System)
IRB # 05-03-28-02

The aim of this study is to examine hemodynamic activation (using fMRI) and white matter tract integrity (using DTI) in a group of bipolars with HSV-1 infection and the high activity allelic form of COMT (Val/Val Homozygous). The purpose is to identify and characterize biological markers of cognitive impairment in a very specific group of individuals with bipolar disorder. We aim to gain a better understanding of the pathologic mechanism involved in cognitive impairment in bipolar disorder and perhaps more importantly identify a population of subjects with the disease for whom anti-viral intervention may ameliorate a substantial burden of disease and disability. For questions about this study, please contact Arnold Bakker at 410-502-0468.